Causes of gynecomastia or man boobs

<<em>strong>”Causes of gynecomastia or man boobs”

Gynecomastia or man boobs is quite common happen to boys during puberty and some adults. Why it happens to some people and not all boys or adults? There are many possible causes of gynecomastia, which you can refer to a long list of causes below (which may sound technical jargons to some of us). However, the common cause is imbalance of androgen hormone (male hormone) against estrogen hormone (female hormone).  You may question why male has female hormone. Every normal male produces very small amount of female hormone but larger quantity of male hormone. Due to the larger volume of male hormone, the body suppresses any female characters/features in any normal male. However, the body produces lower quantity of male hormone than female hormone, man boobs or gynecomastia start to occur.

There are also many possible causes of imbalance of hormone (which causes gynecomastia), such aging and obesity. Body fat can cause conversion of some male hormone to female hormone (in scientific term : aromatization of androstenedione to estrone and testosterone to estradiol).  Body fat tends to increase for old people unless they perform regular exercises. Any drug which suppresses the production of male hormone is also one of the causes, example drug for prostate cancer.

The abuse use of drugs, ie. marijuana, and excessive intake of alcohol can cause man boobs problem. The problem will disappear the moment they stop the intake of the drugs.

Doctors and researchers have been studying of using drugs to stop this conversion of hormones. They have used testolactone to reduce the size of breast but not completely disappear.

It is advisable to check with your doctors or physicians to find out the cause of gynecomastia and type of treatment suitable to you if you suspect that you are having man boobs problem.

List of all the causes of gynecomastia or man boobs

1. Physiological
• Neonatal
• Pubertal
• Aging

2. Pathological
• Idiopathic
• Drug induced
• Increased serum estrogen
• Decreased testosterone synthesis
• Androgen resistance due to androgen receptor defects
• Other

3. Hormones
• Androgens
• Anabolic steroids
• Chorionic gonadotropin
• Estrogens
• Growth hormone

4. Antiandrogens/inhibitors of androgen synthesis
• Cyproterone acetate
• Flutamide
• Finasteride

5. Antibiotics
• Ethionamide
• Isoniazid
• Ketoconazole
• Metronidazole

6. Anti-ulcer drugs
• Cimetidine
• Ranitidine
• Omeprazole

7. Cancer chemotherapeutic drugs
• Alkylating agents
• Methotrexate
• Vinca alkaloids
• Combination chemotherapy

8. Cardiovascular drugs
• Amiodarone
• Captopril
• Digitoxin
• Diltiazem
• Enalapril
• Methyldopa
• Nifedipine
• Reserpine
• Spironolactone
• Verapamil

9. Psychoactive drugs
• Diazepam
• Haloperidol
• Phenothiazines
• Tricyclic antidepressants

10. Drugs of abuse
• Alcohol
• Amphetamines
• Heroin
• Marijuana (phytoestrogens)
• Methadone

11. Other
• Auranofin
• Diethylpropion
• Domperidone
• Etretinate
• Metoclopramide
• Phenytoin
• Penicillamine
• Sulindac
• Theophylline

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